As is the case across Canada, the province of British Columbia is in the midst of an opioid overdose crisis. In response to the devastating impacts of this crisis on youth (under 19 years of age), the provincial government is considering amending the Mental Health Act to allow for involuntary, hospital-based stabilization care of youth following an overdose. This policy change represents one concrete action that the provincial government is exploring in response to public advocacy for enhanced supports for youth who overdose. At this juncture, however, we are concerned that stabilization care requires further interrogation in the context of key, interrelated public health and ethical dimensions pertaining to this legislation. In this commentary, we describe three key areas for public health deliberation (1) the evidence underpinning stabilization care, (2) ethical considerations, and (3) the potential for unintended and unevenly distributed consequences. We then offer ways forward to guide and provide opportunities for a more equitable public health response to the overdose crisis and its impacts on youth. In doing so, we emphasize the need for meaningful engagement of youth as key stakeholders in the development of evidence- and ethics-informed substance use care and policy interventions.School belonging impacts a range of factors, including academic performance, school attendance, relationships with peers and teachers, mental and physical health, and drug and alcohol use. Previous studies have shown that a lack of belonging to one's school is associated with substance use. The objective of the study was to examine the association between low school belongingness and the use of opioids in students in grades 9 through 12 in Ontario, Canada.
Data were gathered from 6418 participants in grades 9-12 who responded to the 2015 Ontario Student Drug Use and Health Survey (OSDUHS). Logistic regression analyses were used to model associations between low school belongingness and opioid use, adjusted for gender, grade, ethnicity, socio-economic status, and living situation.
Overall, low school belongingness was associated with non-prescribed opioid use (OR?=?1.11, 95% CI 1.05-1.17). Feeling unsafe at school (OR?=?1.43, 95% CI 1.23-1.66) was associated with elevated odds of using non-medically prescribed opioids. Girls who felt that they were not a part of their school community were at elevated odds of using opioids (OR?=?1.35, 95% CI 1.16-1.56); this association was not observed among boys.
The findings suggest that low school belongingness may be associated with the use of non-prescribed opioids in students. These findings suggest that school-based interventions aimed at improving social cohesion and feelings of belongingness and safety may be beneficial in reducing the use of non-prescription opioids among adolescents.
The findings suggest that low school belongingness may be associated with the use of non-prescribed opioids in students. These findings suggest that school-based interventions aimed at improving social cohesion and feelings of belongingness and safety may be beneficial in reducing the use of non-prescription opioids among adolescents.Public health interventions for adolescent "obesity prevention" have focused predominantly on individualistic health behaviours (e.g., diet and physical activity) at the expense of recognizing body weight diversity and the array of social factors (e.g., stigma and discrimination of marginalized identities) that may be linked to weight status. Research is needed to examine the extent to which individualistic health behaviours versus social factors contribute to weight status in adolescents. As such, the aim of this study was to investigate the relative contribution of individualistic health behaviours versus social factors to objective and perceptual indices of weight status.
Cross-sectional survey data were collected as part of the Toronto Public Health Student Survey and comprised students 12 to 19years of age (N?=?5515). Measures included perceived and objective weight status, social and demographic factors (e.g., gender, sexual orientation, school connectedness), and health behaviours (e.g., physical aweight status, when considering social factors. These findings challenge the utility of public health approaches that target individualistic behaviours as critical risk factors in "obesity prevention" efforts in adolescence.Fibromyalgia (FM) is a generalized chronic pain condition whose pathophysiology is poorly understood, and both basic and translational research are needed to advance the field. Here we used the Sluka model to test whether FM-like pain in mice would produce detectable brain modifications using resting-state (rs) functional Magnetic Resonance Imaging (fMRI). Mice received intramuscular acid saline treatment, images were acquired at 7 T 5 days post-treatment, and pain thresholds tested 3 weeks post-scanning. Data-driven Independent Component Analysis revealed significant reduction of functional connectivity (FC) across several component pairs, with major changes for the Retrosplenial cortex (RSP) central to the default mode network, and to a lesser extent the Periaqueductal gray (PAG), a key pain processing area. Seed-to-seed analysis focused on 14 pain-related areas showed strongest FC reduction for RSP with several cortical areas (somatosensory, prefrontal and insular), and for PAG with both cortical (somatosensory) and subcortical (habenula, thalamus, parabrachial nucleus) areas. https://www.selleckchem.com/products/cenicriviroc.html RSP-PAG FC was also reduced, and this decreased FC tended to be positively correlated with pain levels at individual subject level. Finally, seed-voxelwise analysis focused on PAG confirmed seed-to-seed findings and, also detected reduced PAG FC with the anterior cingulate cortex, increasingly studied in aversive pain effects. In conclusion, FM-like pain triggers FC alterations in the mouse, which are detected by rs-fMRI and are reminiscent of some human findings. The study reveals the causal fingerprint of FM-like pain in rodents, and indicates that both RSP and PAG connectional patterns could be suitable biomarkers, with mechanistic and translational value, for further investigations.